Huang, QinShi, JiongSun, QiGold, JasonChen, JieyuWu, HongyanYu, HuipingZhang, YifenMashimo, HiroshiYu, ChenggongManasco, TravisGuan, WenyanLauwers, Gregory Y.2016-02-012015Huang, Q., J. Shi, Q. Sun, J. S. Gold, J. Chen, H. Wu, H. Yu, et al. 2015. “Clinicopathological characterisation of small (2 cm or less) proximal and distal gastric carcinomas in a Chinese population.” Pathology 47 (6): 526-532. doi:10.1097/PAT.0000000000000276. http://dx.doi.org/10.1097/PAT.0000000000000276.0031-3025http://nrs.harvard.edu/urn-3:HUL.InstRepos:24983924SummaryClinicopathological characteristics of small gastric carcinoma have not been well defined in Chinese patients. The aim of this study was to investigate and compare small proximal (PGC, n = 111) with distal (DGC, n = 202) gastric carcinoma in 313 consecutive surgically resected small (≤2 cm) gastric carcinomas diagnosed with the WHO criteria. PGC patients were significantly older (average age 63 years versus 59 in DGCs) with a male/female ratio of 3:1. Most tumours were clustered along the lesser curvature (74% in PGCs and 65% in DGCs). Compared to DGCs, PGCs showed a protruded gross pattern significantly more frequently and were significantly better differentiated with a significantly wider histomorphological spectrum. Surprisingly, PGCs were composed of significantly fewer signet-ring cell carcinomas (1% versus 16% in DGCs) but were significantly more deeply invasive, compared to DGCs. Lymph node metastasis was detected in 23% overall, but was significantly less frequent in PGCs (16%) than in DGCs (26%) (p < 0.05). However, the difference in survival between the two groups was not statistically significant. Our results demonstrate that in Chinese patients, PGCs display distinct clinicopathological characteristics, compared to DGCs.en-USCardiaChinesegastric cancerJournal Article2016-02-0110.1097/PAT.0000000000000276