Warfield, Kelly L.Barnard, Dale L.Enterlein, Sven G.Smee, Donald F.Khaliq, MansooraSampath, ArunaCallahan, MichaelRamstedt, UrbanDay, Craig W.2016-05-022016Warfield, Kelly L., Dale L. Barnard, Sven G. Enterlein, Donald F. Smee, Mansoora Khaliq, Aruna Sampath, Michael V. Callahan, Urban Ramstedt, and Craig W. Day. 2016. “The Iminosugar UV-4 is a Broad Inhibitor of Influenza A and B Viruses ex Vivo and in Mice.” Viruses 8 (3): 71. doi:10.3390/v8030071. http://dx.doi.org/10.3390/v8030071.1999-4915http://nrs.harvard.edu/urn-3:HUL.InstRepos:26859870Iminosugars that are competitive inhibitors of endoplasmic reticulum (ER) α-glucosidases have been demonstrated to have antiviral activity against a diverse set of viruses. A novel iminosugar, UV-4B, has recently been shown to provide protection against lethal infections with dengue and influenza A (H1N1) viruses in mice. In the current study, the breadth of activity of UV-4B against influenza was examined ex vivo and in vivo. Efficacy of UV-4B against influenza A and B viruses was shown in primary human bronchial epithelial cells, a principal target tissue for influenza. Efficacy of UV-4B against influenza A (H1N1 and H3N2 subtypes) and influenza B was demonstrated using multiple lethal mouse models with readouts including mortality and weight loss. Clinical trials are ongoing to demonstrate safety of UV-4B and future studies to evaluate antiviral activity against influenza in humans are planned.en-USIminosugarUV-4Binfluenzahuman bronchial epithelial cellsantiviralmiceJournal Article2016-05-0210.3390/v8030071