Scully, Stephen S.Zheng, Shao-LiangWagner, Bridget K.Schreiber, Stuart2016-02-012015Scully, Stephen S., Shao-Liang Zheng, Bridget K. Wagner, and Stuart L. Schreiber. 2015. “Synthesis of Oxazocenones via Gold(I)-Catalyzed 8-Endo-Dig Hydroalkoxylation of Alkynamides.” Organic Letters 17 (3): 418-421. doi:10.1021/ol503273v. http://dx.doi.org/10.1021/ol503273v.1523-7060http://nrs.harvard.edu/urn-3:HUL.InstRepos:24984024Several benzoxazocenones have been found to exhibit novel cellular activities. In the present study, we report a gold(I)-catalyzed 8-endo-dig hydroalkoxylation reaction of alkynamides to access analogous oxazocenone scaffolds. This methodology provided an advanced intermediate, which was elaborated to a des-benzo analog of a bioactive benzoxazocenone.en-USJournal Article2016-02-0110.1021/ol503273v