Bartolozzi IV, Arthur R2017-05-152017-052017-05-122017Bartolozzi IV, Arthur R. 2017. The Forest for the Trees: Using Big Data to Improve Preoperative Assessment and Risk Stratification in Pediatric Orthopedic Surgery. Doctoral dissertation, Harvard Medical School.http://nrs.harvard.edu/urn-3:HUL.InstRepos:32676123This thesis uses the Kid’s Inpatient Database to analyze surgical epidemiology, clinical outcomes, LOS, and total costs for two major pediatric surgeries. The goal is to establish clinically meaningful identifiers of risk, complexity, and variation in management both for improving preoperative assessment and understanding demographic determinants of health. Chapter 1 focused on open hip reduction for the treatment of DDH. This has become more expensive despite shorter hospital stay over time. It is also a longer, more costly experience for children who have reached walking age particularly those over 3 years old. Other patient factors including: developmental delay, ethnicity and insurance, hospital factors, and surgical management contribute to increased LOS and total charges. Despite the conclusions above a more detailed cost-analysis at an institutional level is necessary to identify how the above variables interact with each other. Chapter 2 investigated the pediatric neuromuscular population undergoing primary spinal fusions. Analyses of urinary function and anemia in addition to CCC scoring can be conducted preoperatively to determine likelihood of complications and LOS. Complications are strongly associated with both LOS and total charges and were lower at high volume centers. Additional factors including hospital size, patient race, anterior/posterior surgery, and BMP use were associated with higher charges. We presented individual prediction models for grouping patients by risk for long LOS and high cost.application/pdfenThesis or Dissertation2017-05-15