Levitt, JamesKubicki, MarekNestor, PaulErsner-Hershfield, HalWestin, C-FAlvarado, Jorge L.Kikinis, RonJolesz, FerencMcCarley, Robert WilliamShenton, Martha2016-09-232010Levitt, James J., Marek Kubicki, Paul G. Nestor, Hal Ersner-Hershfield, C-F Westin, Jorge L. Alvarado, Ron Kikinis, Ferenc A. Jolesz, Robert W. McCarley, and Martha E. Shenton. 2010. A Diffusion Tensor Imaging Study of the Anterior Limb of the Internal Capsule in Schizophrenia. Psychiatry Research: Neuroimaging 184, no. 3: 143–150. doi:10.1016/j.pscychresns.2010.08.004.0925-4927http://nrs.harvard.edu/urn-3:HUL.InstRepos:28548989Introduction—Frontal-subcortical cognitive and limbic feedback loops modulate higher cognitive functioning. The final step in these feedback loops is the thalamo-cortical projection through the anterior limb of the internal capsule (AL-IC). Using diffusion tensor imaging (DTI), we evaluated abnormalities in the AL-IC fiber tract in schizophrenia. Methods—16 chronic schizophrenics and 19 male, normal controls group matched for handedness, age, and parental SES, underwent DTI on a 1.5 Tesla GE system. We measured the diffusion indices, fractional anisotropy (FA) mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD), and manually segmented, based on FA maps, AL-IC volume, normalized for intracranial contents (ICC). Results—Results showed a significant reduction in the ICC corrected volume of the AL-IC, in schizophrenia, but did not show diffusion measure group differences in the AL-IC in FA, MD, RD or AD. In addition, results revealed in schizophrenics, AL-IC FA correlated positively with performance on measures of spatial and verbal declarative/episodic memory, and right AL-IC ICC corrected volume correlated positively with more perseverative responses on the Wisconsin Card Sort Test (WCST). Discussion—We found a reduction in AL-IC ICC corrected volume in schizophrenia, without FA, MD, RD or AD group differences, implicating the presence of a structural abnormality in schizophrenia in this subcortical white matter region which contains important cognitive, and limbic feedback pathways which modulate prefrontal cortical function. Despite not demonstrating a group difference in FA, we found that AL-IC FA was a good predictor of spatial and verbal declarative/episodic memory performance in schizophrenia.en-USSchizophreniadiffusion tensor imagingAnterior Limb of the Internal Capsulethalamusprefrontal cortexJournal Article2016-09-2310.1016/j.pscychresns.2010.08.004