Regev-Yochay, GiliTrzcinski, K.Thompson, ClaudetteMalley, RichardLipsitch, Marc2016-05-102006Regev-Yochay, G., K. Trzcinski, C. M. Thompson, R. Malley, and M. Lipsitch. 2006. “Interference Between Streptococcus Pneumoniae and Staphylococcus Aureus: In Vitro Hydrogen Peroxide-Mediated Killing by Streptococcus Pneumoniae.” Journal of Bacteriology 188 (13) (June 20): 4996–5001. doi:10.1128/jb.00317-06. http://dx.doi.org/10.1128/JB.00317-06.0021-9193http://nrs.harvard.edu/urn-3:HUL.InstRepos:26978420The bactericidal activity of Streptococcus pneumoniae toward Staphylococcus aureus is mediated by hydrogen peroxide. Catalase eliminated this activity. Pneumococci grown anaerobically or genetically lacking pyruvate oxidase (SpxB) were not bactericidal, nor were nonpneumococcal streptococci. These results provide a possible mechanistic explanation for the interspecies interference observed in epidemiologic studies.en-USantibiosis*/drug effectscatalase/pharmacologyhydrogen peroxide/pharmacology*microbial sensitivity testspyruvate oxidase/deficiencypyruvate oxidase/geneticsstaphylococcus aureus/drug effectsstaphylococcus aureus/physiology*streptococcus pneumoniae/geneticsstreptococcus pneumoniae/growth & developmentstreptococcus pneumoniae/physiology*Journal Article2016-05-1010.1128/JB.00317-06