Wang, ZhaoxiChoi, SojungLee, JinseonHuang, Yen-TsungChen, FengZhao, YangLin, XihongNeuberg, DonnaKim, JhingookChristiani, David C2015-03-022015Wang, Zhaoxi, Sojung Choi, Jinseon Lee, Yen-Tsung Huang, Feng Chen, Yang Zhao, Xihong Lin, Donna Neuberg, Jhingook Kim, and David C Christiani. 2015. “Mitochondrial Variations in Non-Small Cell Lung Cancer (NSCLC) Survival.” Cancer Informatics 14 (Suppl 1): 1-9. doi:10.4137/CIN.S13976. http://dx.doi.org/10.4137/CIN.S13976.1176-9351http://nrs.harvard.edu/urn-3:HUL.InstRepos:14065375Mutations in the mtDNA genome have long been suspected to play an important role in cancer. Although most cancer cells harbor mtDNA mutations, the question of whether such mutations are associated with clinical prognosis of lung cancer remains unclear. We resequenced the entire mitochondrial genomes of tumor tissue from a population of 250 Korean patients with non-small cell lung cancer (NSCLC). Our analysis revealed that the haplogroup (D/D4) was associated with worse overall survival (OS) of early-stage NSCLC [adjusted hazard ratio (AHR), 1.95; 95% CI, 1.14–3.33; Ptrend = 0.03]. By comparing the mtDNA variations between NSCLC tissues and matched blood samples, we found that haplogroups M/N and/or D/D4 were hotspots for somatic mutations, suggesting a more complicated mechanism of mtDNA somatic mutations other than the commonly accepted mechanism of sequential accumulation of mtDNA mutations.en-USmitochondria genomemitochondria mutationslung cancer survivalhaplogroupmitochondrial genome resequencingJournal Article2015-03-0210.4137/CIN.S13976