Mansour, MichaelTam, JennyKhan, Nida S.Seward, MichaelDavids, Peter J.Puranam, SravanthiSokolovska, AnnaSykes, DavidDagher, ZeinaBecker, ChristineTanne, AntoineReedy, JenniferStuart, Lynda M.Vyas, Jatin2017-11-272013Mansour, Michael K., Jenny M. Tam, Nida S. Khan, Michael Seward, Peter J. Davids, Sravanthi Puranam, Anna Sokolovska, et al. 2013. “Dectin-1 Activation Controls Maturation of β-1,3-Glucan-Containing Phagosomes.” Journal of Biological Chemistry 288 (22) (April 22): 16043–16054. doi:10.1074/jbc.m113.473223.0021-9258http://nrs.harvard.edu/urn-3:HUL.InstRepos:34388154Background: Dectin-1 is able to recognize and phagocytose the fungal carbohydrate, β-1,3-glucan, but its contribution to phagosomal maturation has not been explored. Results: Dectin-1-dependent Syk activation promotes phagolysosomal fusion and acidification. Conclusion: Dectin-1-dependent Syk-activation permits egress of early phagosomes to mature phagolysosomes. Significance: The surface recognition receptor, Dectin-1 shapes anti-fungal responses by controlling fungal phagosome maturation.en-USJournal Article2017-06-0920132017-11-2710.1074/jbc.M113.473223