Klappacher, Günter W.Lunyak, Victoria V.Sykes, DavidSawka-Verhelle, DominiqueSage, JulienBrard, GyanNgo, Sally D.Gangadharan, DeniseJacks, TylerKamps, Mark P.Rose, David W.Rosenfeld, Michael G.Glass, Christopher K.2018-06-202002Klappacher, Günter W., Victoria V. Lunyak, David B. Sykes, Dominique Sawka-Verhelle, Julien Sage, Gyan Brard, Sally D. Ngo, et al. 2002. “An Induced Ets Repressor Complex Regulates Growth Arrest During Terminal Macrophage Differentiation.” Cell 109 (2) (April): 169–180. doi:10.1016/s0092-8674(02)00714-6.0092-8674http://nrs.harvard.edu/urn-3:HUL.InstRepos:37137074Defining the molecular mechanisms that coordinately regulate proliferation and differentiation is a central issue in development. Here, we describe a mechanism in which induction of the Ets repressor METS/PE1 links terminal differentiation to cell cycle arrest. Using macrophages as a model, we provide evidence that METS/PE1 blocks Ras-dependent proliferation without inhibiting Ras-dependent expression of cell type-specific genes by selectively replacing Ets activators on the promoters of cell cycle control genes. Antiproliferative effects of METS require its interaction with DP103, a DEAD box-containing protein that assembles a novel corepressor complex. Functional interactions between the METS/DP103 complex and E2F/ pRB family proteins are also necessary for inhibition of cellular proliferation, suggesting a combinatorial code that directs permanent cell cycle exit during terminal differentiation.en-USJournal Article2017-06-09200210.1016/s0092-8674(02)00714-6