Loggia, MarcoBerna, ChantalKim, JieunCahalan, Christine M.Gollub, RandyWasan, Ajay D.Harris, Richard E.Edwards, RobertNapadow, Vitaly2018-06-202013Loggia, Marco L., Chantal Berna, Jieun Kim, Christine M. Cahalan, Randy L. Gollub, Ajay D. Wasan, Richard E. Harris, Robert R. Edwards, and Vitaly Napadow. 2013. “Disrupted Brain Circuitry for Pain-Related Reward/Punishment in Fibromyalgia.” Arthritis & Rheumatology 66 (1) (December 30): 203–212. doi:10.1002/art.38191.2326-5191http://nrs.harvard.edu/urn-3:HUL.InstRepos:37140365Objective While patients suffering from fibromyalgia (FM) are known to exhibit hyperalgesia, the central mechanisms contributing to this altered pain processing are not fully understood. In this study we investigate potential dysregulation of the neural circuitry underlying cognitive and hedonic aspects of the subjective experience of pain such as anticipation of pain and of pain relief. Methods FMRI was performed on 31 FM patients and 14 controls while they received cuff pressure pain stimuli on their leg, calibrated to elicit a pain rating of ∼50/100. During the scan, subjects also received visual cues informing them of impending pain onset (pain anticipation) and pain offset (relief anticipation). Results Patients exhibited less robust activations during both anticipation of pain and anticipation of relief within regions commonly thought to be involved in sensory, affective, cognitive and pain-modulatory processes. In healthy controls, direct searches and region-of-interest analyses in the ventral tegmental area (VTA) revealed a pattern of activity compatible with the encoding of punishment: activation during pain anticipation and pain stimulation, but deactivation during relief anticipation. In FM patients, however, VTA activity during pain and anticipation (of both pain and relief) periods was dramatically reduced or abolished. Conclusion FM patients exhibit disrupted brain responses to reward/punishment. The VTA is a source for reward-linked dopaminergic/GABAergic neurotransmission in the brain and our observations are compatible with reports of altered dopaminergic/GABAergic neurotransmission in FM. Reduced reward/punishment signaling in FM may relate to the augmented central processing of pain and reduced efficacy of opioid treatments in these patients.en-USJournal Article2017-07-1720142018-06-2010.1002/art.38191