Hadjikhani, NouchineWard, NoreenBoshyan, JasmineNapadow, VitalyMaeda, YumiTruini, AndreaCaramia, FrancescaTinelli, EmanueleMainero, Caterina2018-05-032013Hadjikhani, Nouchine, Noreen Ward, Jasmine Boshyan, Vitaly Napadow, Yumi Maeda, Andrea Truini, Francesca Caramia, Emanuele Tinelli, and Caterina Mainero. 2013. “The Missing Link: Enhanced Functional Connectivity Between Amygdala and Visceroceptive Cortex in Migraine.” Cephalalgia 33 (15) (May 29): 1264–1268. doi:10.1177/0333102413490344.0333-1024http://nrs.harvard.edu/urn-3:HUL.InstRepos:36640545Background Migraine is a neurovascular disorder, in which altered functional connectivity between pain-modulating circuits and the limbic system may play a role. Cortical spreading depression (CSD), which underlies migraine aura induces C-fos expression in the amygdala. The role of CSD, and amygdala connectivity, in migraine without aura (MwoA) is less clear and may differentiate migraine from other chronic pain disorders. Results Amygdala connectivity in both migraine with aura (MWA) and MWoA was increased to the visceroceptive insula relative to healthy subjects and two other chronic pain conditions not associated with CSD: trigeminal neuralgia (TGN) and carpal tunnel syndrome (CTS). Conclusion The observed increased connectivity within the limbic/viscerosensory network, present only in migraineurs, adds to the evidence of a neurolimbic pain network dysfunction, and may reflect repetitive episodes of CSD leading to the development of migraine pain.en-UScortical spreading depressionmigraineneurolimbic pain networkinsulaamygdalaJournal Article2017-07-1720132018-05-0310.1177/0333102413490344