Godlewski, JakubFerrer-Luna, RubenRooj, ArunMineo, MarcoRicklefs, FranzTakeda, Yuji S.Nowicki, M. OskarSalińska, ElżbietaNakano, IchiroLee, HakhoWeissleder, RalphBeroukhim, RameenChiocca, E.Bronisz, Agnieszka2017-07-242017Godlewski, J., R. Ferrer-Luna, A. K. Rooj, M. Mineo, F. Ricklefs, Y. S. Takeda, M. O. Nowicki, et al. 2017. “MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer.” Stem Cell Reports 8 (6): 1497-1505. doi:10.1016/j.stemcr.2017.04.024. http://dx.doi.org/10.1016/j.stemcr.2017.04.024.http://nrs.harvard.edu/urn-3:HUL.InstRepos:33490876Summary Despite the importance of molecular subtype classification of glioblastoma (GBM), the extent of extracellular vesicle (EV)-driven molecular and phenotypic reprogramming remains poorly understood. To reveal complex subpopulation dynamics within the heterogeneous intratumoral ecosystem, we characterized microRNA expression and secretion in phenotypically diverse subpopulations of patient-derived GBM stem-like cells (GSCs). As EVs and microRNAs convey information that rearranges the molecular landscape in a cell type-specific manner, we argue that intratumoral exchange of microRNA augments the heterogeneity of GSC that is reflected in highly heterogeneous profile of microRNA expression in GBM subtypes.en-UScancer stem cellssubtypesglioblastomaGBMcancer heterogeneitymicroRNAexosomesextracellular vesiclesJournal Article2017-07-2410.1016/j.stemcr.2017.04.024