Yuan, HuaLiu, HongliangLiu, ZhenshengOwzar, KourosHan, YounghunSu, LiWei, YongyueHung, Rayjean J.McLaughlin, JohnBrhane, YonathanBrennan, PaulBickeboeller, HeikeRosenberger, AlbertHoulston, Richard S.Caporaso, NeilLandi, Maria TeresaHeinrich, JoachimRisch, AngelaChristiani, DavidGümüş, Zeynep H.Klein, Robert J.Amos, Christopher I.Wei, Qingyi2016-11-182016Yuan, H., H. Liu, Z. Liu, K. Owzar, Y. Han, L. Su, Y. Wei, et al. 2016. “A Novel Genetic Variant in Long Non-coding RNA Gene NEXN-AS1 is Associated with Risk of Lung Cancer.” Scientific Reports 6 (1): 34234. doi:10.1038/srep34234. http://dx.doi.org/10.1038/srep34234.2045-2322http://nrs.harvard.edu/urn-3:HUL.InstRepos:29408404Lung cancer etiology is multifactorial, and growing evidence has indicated that long non-coding RNAs (lncRNAs) are important players in lung carcinogenesis. We performed a large-scale meta-analysis of 690,564 SNPs in 15,531 autosomal lncRNAs by using datasets from six previously published genome-wide association studies (GWASs) from the Transdisciplinary Research in Cancer of the Lung (TRICL) consortium in populations of European ancestry. Previously unreported significant SNPs (P value < 1 × 10−7) were further validated in two additional independent lung cancer GWAS datasets from Harvard University and deCODE. In the final meta-analysis of all eight GWAS datasets with 17,153 cases and 239,337 controls, a novel risk SNP rs114020893 in the lncRNA NEXN-AS1 region at 1p31.1 remained statistically significant (odds ratio = 1.17; 95% confidence interval = 1.11–1.24; P = 8.31 × 10−9). In further in silico analysis, rs114020893 was predicted to change the secondary structure of the lncRNA. Our finding indicates that SNP rs114020893 of NEXN-AS1 at 1p31.1 may contribute to lung cancer susceptibility.en-USJournal Article2016-11-1810.1038/srep34234