Kantar, Rami S.Lashgari, GhazalTabet, Elie I.Lewandrowski, Grant K.Carvalho, LitiaTannous, Bakhos2016-07-142016Kantar, Rami S., Ghazal Lashgari, Elie I. Tabet, Grant K. Lewandrowski, Litia A. Carvalho, and Bakhos A. Tannous. 2016. “Imaging Tumor Vascularity and Response to Anti-Angiogenic Therapy Using Gaussia Luciferase.” Scientific Reports 6 (1): 26353. doi:10.1038/srep26353. http://dx.doi.org/10.1038/srep26353.2045-2322http://nrs.harvard.edu/urn-3:HUL.InstRepos:27662097We developed a novel approach to assess tumor vascularity using recombinant Gaussia luciferase (rGluc) protein and bioluminescence imaging. Upon intravenous injection of rGluc followed by its substrate coelenterazine, non-invasive visualization of tumor vascularity by bioluminescence imaging was possible. We applied this method for longitudinal monitoring of tumor vascularity in response to the anti-angiogenic drug tivozanib. This simple and sensitive method could be extended to image blood vessels/vasculature in many different fields.en-USJournal Article2016-07-1410.1038/srep26353