Hochbaum, Allon I.Aizenberg, Joanna2016-06-302010Hochbaum, Allon I., and Joanna Aizenberg. 2010. Bacteria Pattern Spontaneously on Periodic Nanostructure Arrays. Nano Lett. 10, no. 9: 3717–3721. doi:10.1021/nl102290k.1530-6984http://nrs.harvard.edu/urn-3:HUL.InstRepos:27417439Surface-associated bacteria typically form self-organizing communities called biofilms. Spatial segregation is important for various bacterial processes associated with cellular and community development. Here, we demonstrate bacterial ordering and oriented attachment on the single-cell level induced by nanometer-scale periodic surface features. These surfaces cause spontaneous and distinct patterning phases, depending on their periodicity, which is observed for several strains, both gram positive and negative. This patterning is a general phenomenon that can control natural biofilm organization.en-USnanobiointerfacebacteriabiofilmself-assemblynanopostsJournal Article2016-06-3010.1021/nl102290k