Gianella, AnitaMieszawska, Aneta J.Hoeben, Freek J. M.Janssen, Henk M.Jarzyna, Peter A.Cormode, David P.Costa, Kevin D.Rao, SatishFarokhzad, OmidLanger, RobertFayad, Zahi A.Mulder, Willem J. M.2016-10-142013Gianella, Anita, Aneta J. Mieszawska, Freek J. M. Hoeben, Henk M. Janssen, Peter A. Jarzyna, David P. Cormode, Kevin D. Costa, et al. 2013. “Synthesis and in Vitro Evaluation of a Multifunctional and Surface-Switchable Nanoemulsion Platform.” Chemical Communications 49 (82): 9392. doi:10.1039/c3cc43618g.1359-7345http://nrs.harvard.edu/urn-3:HUL.InstRepos:29010448We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and the targeting ligands become available for binding. The concept was evaluated in vitro using the biotin and αvβ3-integrin-specific RGD-peptide functionalized nanoparticles.en-USJournal Article2016-10-1410.1039/c3cc43618g