Kim, YongTaeLee Chung, BomyMa, MingmingMulder, Willem J. M.Fayad, Zahi A.Farokhzad, OmidLanger, Robert2020-04-282012Kim, YongTae, Bomy Lee Chung, Mingming Ma, Willem J. M. Mulder, Zahi A. Fayad, Omid C. Farokhzad, and Robert Langer. 2012. “Mass Production and Size Control of Lipid–Polymer Hybrid Nanoparticles through Controlled Microvortices.” Nano Lett. 12 (7) (July 11): 3587–3591. doi:10.1021/nl301253v.1530-6984http://nrs.harvard.edu/urn-3:HUL.InstRepos:42661842Lipid-polymer hybrid (LPH) nanoparticles can deliver a wide range of therapeutic compounds in a controlled manner. LPH nanoparticle syntheses using microfluidics improve the mixing process, but are restricted by a low throughput. In this study we present a pattern-tunable microvortex platform that allows mass production and size control of LPH nanoparticles with superior reproducibility and homogeneity. We demonstrate that by varying flow rates (i.e. Reynolds number (30∼150)) we can control the nanoparticle size (30∼170nm) with high productivity (∼3g/hour) and low polydispersity (∼0.1). Our approach may contribute to efficient development and optimization of a wide range of multicomponent nanoparticles for medical imaging and drug delivery.en-USNanoparticleMicrovortexSynthesisControlPolymerMicrofluidicsJournal Article2020-04-2810.1021/nl301253v