Priolo, CarmenLoda, Massimo2016-07-142015Priolo, Carmen, and Massimo Loda. 2015. “Untargeted metabolomics for profiling oncogene-specific metabolic signatures of prostate cancer.” Molecular & Cellular Oncology 2 (4): e1001197. doi:10.1080/23723556.2014.1001197. http://dx.doi.org/10.1080/23723556.2014.1001197.2372-3556http://nrs.harvard.edu/urn-3:HUL.InstRepos:27662192Oncogene-associated metabolic signatures in prostate cancer, identified by an integrative analysis of cultured cells and murine and human tumors, suggest that AKT activation results in a glycolytic phenotype whereas MYC induces aberrant lipid metabolism. Heterogeneity in human tumors makes this simplistic interpretation obtained from experimental models more challenging. Metabolic reprogramming as a function of distinct molecular aberrations has major diagnostic and therapeutic implications.en-USAKT signalingcancer metabolismmass spectrometryMYCprostate cancerJournal Article2016-07-1410.1080/23723556.2014.1001197