Meng, ShashaDe Vivo, ImmaculataLiang, LimingHu, ZhibinChristiani, DavidGiovannucci, EdwardHan, Jiali2016-11-182016Meng, Shasha, Immaculata De Vivo, Liming Liang, Zhibin Hu, David C. Christiani, Edward Giovannucci, and Jiali Han. 2016. “Pre-diagnostic leukocyte mitochondrial DNA copy number and risk of lung cancer.” Oncotarget 7 (19): 27307-27312. doi:10.18632/oncotarget.8426. http://dx.doi.org/10.18632/oncotarget.8426.1949-2553http://nrs.harvard.edu/urn-3:HUL.InstRepos:29408432We prospectively investigated the relationship between mtCN and the risk of lung cancer in 463 case-control pairs from two prospective cohort studies, the Nurses’ Health Study (NHS) and the Health Professionals Follow-Up Study (HPFS). The adjusted least-squares means of log-transformed mtCN (log_mtCN) by smoking status were estimated by generalized linear models. Multivariable conditional logistic regression model adjusting for confounders was used to obtain the odds ratios (ORs) and 95% confidence intervals (CIs) for the association between log_mtCN and lung cancer risk. The adjusted least-squares mean of log_mtCN in heavy smokers was significantly lower than that in never smokers (P = 0.05). Compared to the high log_mtCN group, the risk of lung cancer was 1.29 (95% CI = 0.89–1.87) for the median group, and 1.11 (95% CI = 0.75–1.64) for the low group. Among current smokers, compared to participants with high levels of log_mtCN, those with median levels had a significantly higher risk of lung cancer (OR = 2.09; 95% CI = 1.12–3.90), but not those with low levels (OR = 1.37; 95% CI = 0.75–2.48). Further studies are warranted to confirm these findings.en-USmitochondrial DNA copy numberlung cancer riskoxidative stressprospective cohortcase-control studyJournal Article2016-11-1810.18632/oncotarget.8426