Mandavia, AmarRobinson, Gabriella G. N.Bradley, BekhRessler, KerryPowers, Abigail2017-01-032016Mandavia, Amar, Gabriella G. N. Robinson, Bekh Bradley, Kerry J. Ressler, and Abigail Powers. 2016. “Exposure to Childhood Abuse and Later Substance Use: Indirect Effects of Emotion Dysregulation and Exposure to Trauma.” Journal of Traumatic Stress 29 (5): 422-429. doi:10.1002/jts.22131. http://dx.doi.org/10.1002/jts.22131.0894-9867http://nrs.harvard.edu/urn-3:HUL.InstRepos:29738982Little is known about how emotion dysregulation (ED) and trauma exposure differentially affect the relationship between abuse in childhood and adult substance use. We examined associations between child abuse, trauma exposure, ED, and current substance use in an already existing dataset. Participants (N = 2,014 adults, 90% African American) had been recruited from an urban hospital for a parent study. Analyses showed that drug and alcohol use was significantly positively correlated with child abuse (emotional, physical, and sexual), later trauma exposure, and ED (all ps < .001). Linear regression showed that exposure to abuse when older than a child was significantly associated with drug and alcohol use independent of child abuse and demographic variables (R 2Δ = .08, p < .001; R 2Δ = .04, p < .001). ED was significantly associated with drug and alcohol use independently of child abuse, nonabuse trauma, and demographic variables (R 2Δ = .02, p < .001; R 2Δ = .04, p < .001). Multiple mediation analyses showed that ED and later trauma exposure accounted for variance in the association between emotional abuse and substance use (p < .001). A better understanding of vulnerabilities to additional traumatization and emotion‐regulation deficits in individuals who have been exposed to child abuse and in addition have comorbid substance use problems may inform treatments that lead to improved outcomes.en-USJournal Article2017-01-0310.1002/jts.22131