Chittenden, ThomasHowe, Eleanor A.Culhane, AedinSultana, RazvanTaylor, Jennifer M.Holmes, ChrisQuackenbush, John2016-09-302008Chittenden, Thomas W., Eleanor A. Howe, Aedin C. Culhane, Razvan Sultana, Jennifer M. Taylor, Chris Holmes, and John Quackenbush. 2008. “Functional Classification Analysis of Somatically Mutated Genes in Human Breast and Colorectal Cancers.” Genomics 91 (6) (June): 508–511. doi:10.1016/j.ygeno.2008.03.002.0888-7543http://nrs.harvard.edu/urn-3:HUL.InstRepos:28724492A recent study published by Sjoblom and colleagues performed comprehensive sequencing of 13,023 human genes and identified mutations in genes specific to breast and colorectal tumors, providing insight into organ-specific tumor biology. Here we present a systematic analysis of the functional classifications of Sjoblom’s “CAN” genes, a subset of these validated mutant genes that identify novel organ-specific biological themes and molecular pathways associated with diseasespecific etiology. This analysis links four somatically mutated genes associated with diverse oncological types to colorectal and breast cancers through established TGF-β1 regulated interactions, revealing mechanistic differences in these cancers and providing potential diagnostic and therapeutic targets.en-USBreast CancerColorectal CancerGenomicsBioinformaticsJournal Article2016-09-3010.1016/j.ygeno.2008.03.002