Yang, ShangbinHe, ShunZhou, XiaoboLiu, MeiZhu, HongxiaWang, YihuaZhang, WeiYan, ShuangQuan, LanpingBai, JingfengXu, Ningzhi2017-05-152010Yang, Shangbin, Shun He, Xiaobo Zhou, Mei Liu, Hongxia Zhu, Yihua Wang, Wei Zhang, et al. 2010. Suppression of Aurora-A Oncogenic Potential by c-Myc Downregulation. Exp Mol Med 42, no. 11: 759. doi:10.3858/emm.2010.42.11.077.1226-3613http://nrs.harvard.edu/urn-3:HUL.InstRepos:32684116The abnormality of serine/threonine kinase Aurora-A is seen in many types of cancers. Although in physiological context it has been shown to play a vital role in cellular mitosis, how this oncogene contributes to tumorigenesis remains unclear. Here we demonstrate that Aurora-A overexpression enhances both the expression level and transcriptional activity of c-Myc. The inhibition of c-Myc expression by RNA interference significantly impaired the oncogenic potential of Aurora-A, resulting in attenuated cellular proliferation and transformation rates as well as fewer centrosomal aberrations. Furthermore, downregulation of c-Myc effectively overcame Aurora-A-induced resistance to cisplatin in esophageal cancer cells. Taken together, our results suggest an important role for c-Myc in mediating the oncogenic activity of Aurora-A, which may in turn allow for future targeting of c-Myc as a potential therapeutic strategy for tumors with Aurora-A overexpression.en-USaurora kinaseneoplasmsproto-oncogene proteins c-mycRNA interferenceJournal Article2017-05-1510.3858/emm.2010.42.11.077