Cohen, TedLipsitch, Marc2016-02-252008Cohen, Ted, and Marc Lipsitch. 2008. “Too Little of a Good Thing.” Epidemiology 19 (4) (July): 588–589. doi:10.1097/ede.0b013e31817734ba.1044-3983http://nrs.harvard.edu/urn-3:HUL.InstRepos:25620503Epidemic theory dictates that a reduction in the force of infection by a pathogen is associated with an increase in the average age at which individuals are exposed. For those pathogens that cause more severe disease among hosts of an older age, interventions that limit transmission can paradoxically increase the burden of disease in a population.en-USage factorsbacterial infections/immunologydisease transmission, infectious/prevention & controlenvironmental exposurefood microbiologyimmunityimmunizationinfection control/methodsvirulenceJournal Article2015-12-30Marc Lipsitch2016-02-2510.1097/EDE.0b013e31817734ba