Poliseno, LauraMarranci, AndreaPandolfi, Pier Paolo2015-11-032015Poliseno, Laura, Andrea Marranci, and Pier Paolo Pandolfi. 2015. “Pseudogenes in Human Cancer.” Frontiers in Medicine 2 (1): 68. doi:10.3389/fmed.2015.00068. http://dx.doi.org/10.3389/fmed.2015.00068.2296-858Xhttp://nrs.harvard.edu/urn-3:HUL.InstRepos:23474009Recent advances in the analysis of RNA sequencing data have shown that pseudogenes are highly specific markers of cell identity and can be used as diagnostic and prognostic markers. Furthermore, genetically engineered mouse models have recently provided compelling support for a causal link between altered pseudogene expression and cancer. In this review, we discuss the most recent milestones reached in the pseudogene field and the use of pseudogenes as cancer classifiers.en-USReviewpseudogenescancerdiagnostic markersprognostic markersceRNAsanimal models of cancermutagenic factorsJournal Article2015-11-0310.3389/fmed.2015.00068