Choi, Won IlKamaly, NazilaRiol-Blanco, LorenaLee, In-HyunWu, JunSwami, ArchanaVilos, CristianYameen, BasitYu, MikyungShi, JinjunTabas, Iravon Andrian-Werburg, UlrichJon, SangyongFarokhzad, Omid2015-11-032014Choi, W. I., N. Kamaly, L. Riol-Blanco, I. Lee, J. Wu, A. Swami, C. Vilos, et al. 2014. “A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins.” Nano Letters 14 (11): 6449-6455. doi:10.1021/nl502994y. http://dx.doi.org/10.1021/nl502994y.1530-6984http://nrs.harvard.edu/urn-3:HUL.InstRepos:23474013Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a solvent-free polymer thermo-expansion mechanism with clinical potential, capable of effectively delivering a range of therapeutic proteins in a sustained manner with no loss of bioactivity, with improved biological half-lives and efficacy in vivo.en-USNanoparticlesthermospongesolvent-freetherapeutic proteinsbiologicsJournal Article2015-11-0310.1021/nl502994y