Ghassibe-Sabbagh, MichellaHaber, MarcSalloum, Angelique K.Al-Sarraj, YasserAkle, YasmineHirbli, KamalRomanos, JihaneMouzaya, FrancisGauguier, DominiquePlatt, Daniel E.El-Shanti, HatemZalloua, Pierre2017-05-012014Ghassibe-Sabbagh, M., M. Haber, A. K. Salloum, Y. Al-Sarraj, Y. Akle, K. Hirbli, J. Romanos, et al. 2014. “T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility.” Scientific Reports 4 (1): 7351. doi:10.1038/srep07351. http://dx.doi.org/10.1038/srep07351.http://nrs.harvard.edu/urn-3:HUL.InstRepos:32630665Genome-wide association studies (GWAS) of multiple populations with distinctive genetic and lifestyle backgrounds are crucial to the understanding of Type 2 Diabetes Mellitus (T2DM) pathophysiology. We report a GWAS on the genetic basis of T2DM in a 3,286 Lebanese participants. More than 5,000,000 SNPs were directly genotyped or imputed using the 1000 Genomes Project reference panels. We identify genome-wide significant variants in two loci CDKAL1 and TCF7L2, independent of sex, age and BMI, with leading variants rs7766070 (OR = 1.39, P = 4.77 × 10−9) and rs34872471 (OR = 1.35, P = 1.01 × 10−8) respectively. The current study is the first GWAS to find genomic regions implicated in T2DM in the Lebanese population. The results support a central role of CDKAL1 and TCF7L2 in T2DM susceptibility in Southwest Asian populations and provide a plausible component for understanding molecular mechanisms involved in the disease.en-USJournal Article2017-05-0110.1038/srep07351