Carreras-Sureda, AmadoPihán, PhilippeHetz, Claudio2017-05-012017Carreras-Sureda, Amado, Philippe Pihán, and Claudio Hetz. 2017. “The Unfolded Protein Response: At the Intersection between Endoplasmic Reticulum Function and Mitochondrial Bioenergetics.” Frontiers in Oncology 7 (1): 55. doi:10.3389/fonc.2017.00055. http://dx.doi.org/10.3389/fonc.2017.00055.http://nrs.harvard.edu/urn-3:HUL.InstRepos:32630666Endoplasmic reticulum (ER) to mitochondria communication has emerged in recent years as a signaling hub regulating cellular physiology with a relevant contribution to diseases including cancer and neurodegeneration. This functional integration is exerted through discrete interorganelle structures known as mitochondria-associated membranes (MAMs). At these domains, ER/mitochondria physically associate to dynamically adjust metabolic demands and the response to stress stimuli. Here, we provide a focused overview of how the ER shapes the function of the mitochondria, giving a special emphasis to the significance of local signaling of the unfolded protein response at MAMs. The implications to cell fate control and the progression of cancer are also discussed.en-USMini Reviewmitochondria-associated membranesunfolded protein responseendoplasmic reticulum stressmitochondriacancerJournal Article2017-05-0110.3389/fonc.2017.00055