Kar, S. P.Beesley, J.Amin Al Olama, A.Michailidou, K.Tyrer, J.Kote-Jarai, Z.Lawrenson, K.Lindstrom, S.Ramus, S. J.Thompson, D. J.Kibel, AdamDansonka-Mieszkowska, A.Michael, A.Dieffenbach, A. K.Gentry-Maharaj, A.Whittemore, A. S.Wolk, A.Monteiro, A.Peixoto, A.Kierzek, A.Cox, A.Rudolph, A.Gonzalez-Neira, A.Wu, A. H.Lindblom, A.Swerdlow, A.Ziogas, A.Ekici, A. B.Burwinkel, B.Karlan, B. Y.Nordestgaard, B. G.Blomqvist, C.Phelan, C.McLean, C.Pearce, C. L.Vachon, C.Cybulski, C.Slavov, C.Stegmaier, C.Maier, C.Ambrosone, C. B.Hogdall, C. K.Teerlink, C. C.Kang, D.Tessier, D. C.Schaid, D. J.Stram, D. O.Cramer, DanielNeal, D. E.Eccles, D.Flesch-Janys, D.Edwards, D. R. V.Wokozorczyk, D.Levine, D. A.Yannoukakos, D.Sawyer, E. J.Bandera, E. V.Poole, Elizabeth M.Goode, E. L.Khusnutdinova, E.Hogdall, E.Song, FBruinsma, F.Heitz, F.Modugno, F.Hamdy, F. C.Wiklund, F.Giles, G. G.Olsson, H.Wildiers, H.Ulmer, H.-U.Pandha, H.Risch, H. A.Darabi, H.Salvesen, H. B.Nevanlinna, H.Gronberg, H.Brenner, H.Brauch, H.Anton-Culver, H.Song, H.Lim, H.-Y.McNeish, I.Campbell, I.Vergote, I.Gronwald, J.Lubinski, J.Stanford, J. L.Benitez, J.Doherty, J. A.Permuth, J. B.Chang-Claude, J.Donovan, J. L.Dennis, J.Schildkraut, J. M.Schleutker, J.Hopper, J. L.Kupryjanczyk, J.Park, J. Y.Figueroa, J.Clements, J. A.Knight, J. A.Peto, J.Cunningham, J. M.Pow-Sang, J.Batra, J.Czene, K.Lu, K. H.Herkommer, K.Khaw, K.-T.Matsuo, K.Muir, K.Offitt, K.Chen, K.Moysich, K. B.Aittoma ki, K.Odunsi, K.Kiemeney, L. A.Massuger, L. F. A. G.Fitzgerald, L. M.Cook, L. S.Cannon-Albright, L.Hooning, M. J.Pike, M. C.Bolla, M. K.Luedeke, M.Teixeira, M. R.Goodman, M. T.Schmidt, M. K.Riggan, M.Aly, M.Rossing, M. A.Beckmann, M. W.Moisse, M.Sanderson, M.Southey, M. C.Jones, M.Lush, M.Hildebrandt, M. A. T.Hou, M.-F.Schoemaker, M. J.Garcia-Closas, M.Bogdanova, N.Rahman, N.Le, N. D.Orr, N.Wentzensen, N.Pashayan, N.Peterlongo, P.Guenel, P.Brennan, P.Paulo, P.Webb, P. M.Broberg, P.Fasching, P. A.Devilee, P.Wang, Q.Cai, Q.Li, Q.Kaneva, R.Butzow, R.Kopperud, R. K.Schmutzler, R. K.Stephenson, R. A.MacInnis, R. J.Hoover, R. N.Winqvist, R.Ness, R.Milne, R. L.Travis, R. C.Benlloch, S.Olson, S. H.McDonnell, S. K.Tworoger, ShelleyMaia, S.Berndt, S.Lee, S. C.Teo, S.-H.Thibodeau, S. N.Bojesen, S. E.Gapstur, S. M.Kjaer, S. K.Pejovic, T.Tammela, T. L. J.Do rk, T.Bru ning, T.Wahlfors, T.Key, T. J.Edwards, T. L.Menon, U.Hamann, U.Mitev, V.Kosma, V.-M.Setiawan, V. W.Kristensen, V.Arndt, V.Vogel, W.Zheng, W.Sieh, W.Blot, W. J.Kluzniak, W.Shu, X.-O.Gao, Y.-T.Schumacher, F.Freedman, M. L.Berchuck, A.Dunning, A. M.Simard, J.Haiman, C. A.Spurdle, A.Sellers, T. A.Hunter, DavidHenderson, B. E.Kraft, PeterChanock, S. J.Couch, F. J.Hall, P.Gayther, S. A.Easton, D. F.Chenevix-Trench, G.Eeles, R.Pharoah, P. D. P.Lambrechts, D.undefined, undefined2017-09-082016Kar, S. P., J. Beesley, A. Amin Al Olama, K. Michailidou, J. Tyrer, Z. Kote-Jarai, K. Lawrenson, et al. 2016. “Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types.” Cancer Discovery 6 (9) (July 17): 1052–1067. doi:10.1158/2159-8290.cd-15-1227.2159-8274http://nrs.harvard.edu/urn-3:HUL.InstRepos:33840773Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest GWA meta-analysis data sets for these cancers totaling 112,349 cases and 116,421 controls of European ancestry, all together and in pairs, identified at P < 10(-8) seven new cross-cancer loci: three associated with susceptibility to all three cancers (rs17041869/2q13/BCL2L11; rs7937840/11q12/INCENP; rs1469713/19p13/GATAD2A), two breast and ovarian cancer risk loci (rs200182588/9q31/SMC2; rs8037137/15q26/RCCD1), and two breast and prostate cancer risk loci (rs5013329/1p34/NSUN4; rs9375701/6q23/L3MBTL3). Index variants in five additional regions previously associated with only one cancer also showed clear association with a second cancer type. Cell-type-specific expression quantitative trait locus and enhancer-gene interaction annotations suggested target genes with potential cross-cancer roles at the new loci. Pathway analysis revealed significant enrichment of death receptor signaling genes near loci with P < 10(-5) in the three-cancer meta-analysis.en-USbreast cancerovarian cancerprostate cancergenome-wide association studiespleiotropyJournal Article2017-05-1320162017-09-0810.1158/2159-8290.CD-15-1227