Paternoster, LaviniaStandl, MarieWaage, JohannesBaurecht, HansjörgHotze, MelanieStrachan, David PCurtin, John ABønnelykke, KlausTian, ChaoTakahashi, AtsushiEsparza-Gordillo, JorgeAlves, Alexessander CoutoThyssen, Jacob Pden Dekker, Herman TFerreira, Manuel AAltmaier, ElisabethSleiman, Patrick MAXiao, Feng LiGonzalez, Juan RMarenholz, IngoKalb, BirgitYanes, Maria PinoXu, Cheng-JianCarstensen, LisbethGroen-Blokhuis, Maria MVenturini, CristinaPennell, Craig EBarton, Sheila JLevin, Albert MCurjuric, IvanBustamante, MarionaKreiner-Møller, EskilLockett, Gabrielle ABacelis, JonasBunyavanich, SupindaMyers, Rachel AMatanovic, AnjaKumar, AshishTung, Joyce YHirota, TomomitsuKubo, MichiakiMcArdle, Wendy LHenderson, A JKemp, John PZheng, JieSmith, George DaveyRüschendorf, FranzBauerfeind, AnjaLee-Kirsch, Min AeArnold, AndreasHomuth, GeorgSchmidt, Carsten OMangold, ElisabethCichon, SvenKeil, ThomasRodríguez, ElkePeters, AnnetteFranke, AndreLieb, WolfgangNovak, NatalijaFölster-Holst, ReginaHorikoshi, MomokoPekkanen, JuhaSebert, SylvainHusemoen, Lise LGrarup, Nielsde Jongste, Johan CRivadeneira, FernandoHofman, AlbertJaddoe, Vincent WVPasmans, Suzanne GMAElbert, Niels JUitterlinden, André GMarks, Guy BThompson, Philip JMatheson, Melanie CRobertson, Colin FRied, Janina SLi, JinZuo, Xian BoZheng, Xiao DongYin, Xian YongSun, Liang DanMcAleer, Maeve AO'Regan, Grainne MFahy, Caoimhe MRCampbell, Linda EMacek, MilanKurek, MichaelHu, DongleiEng, CelestePostma, Dirkje SFeenstra, BjarkeGeller, FrankHottenga, Jouke JanMiddeldorp, Christel MHysi, PirroBataille, VeroniqueSpector, TimTiesler, Carla MTThiering, ElisabethPahukasahasram, BadriYang, James JImboden, MedeaHuntsman, ScottVilor-Tejedor, NatàliaRelton, Caroline LMyhre, RonnyNystad, WencheCustovic, AdnanWeiss, ScottMeyers, Deborah ASöderhäll, CillaMelén, ErikOber, CaroleRaby, BenjaminSimpson, AngelaJacobsson, BoHolloway, John WBisgaard, HansSunyer, JordiHensch, Nicole M ProbstWilliams, L KeokiGodfrey, Keith MWang, Carol ABoomsma, Dorret IMelbye, MadsKoppelman, Gerard HJarvis, DeborahMcLean, WH IrwinIrvine, Alan DZhang, Xue JunHakonarson, HakonGieger, ChristianBurchard, Esteban GMartin, Nicholas GDuijts, LiesbethLinneberg, AllanJarvelin, Marjo-RiittaNoethen, Markus MLau, SusanneHübner, NorbertLee, Young-AeTamari, MayumiHinds, David AGlass, DanielBrown, Sara JHeinrich, JoachimEvans, David MWeidinger, Stephan2016-06-142015Paternoster, L., M. Standl, J. Waage, H. Baurecht, M. Hotze, D. P. Strachan, J. A. Curtin, et al. 2015. “Multi-ethnic genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.” Nature genetics 47 (12): 1449-1456. doi:10.1038/ng.3424. http://dx.doi.org/10.1038/ng.3424.1061-4036http://nrs.harvard.edu/urn-3:HUL.InstRepos:27320465Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified 10 novel risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with novel secondary signals at 4 of these). Notably, the new loci include candidate genes with roles in regulation of innate host defenses and T-cell function, underscoring the important contribution of (auto-)immune mechanisms to atopic dermatitis pathogenesis.en-USJournal Article2016-06-1410.1038/ng.3424