A sharp end to sugary Wingless travels

Droujinine, IliaYan, DongPerrimon, Norbert2015-04-012014Droujinine, Ilia A., Dong Yan, and Norbert Perrimon. 2014. “A sharp end to sugary Wingless travels.” The Journal of Cell Biology 206 (7): 819-821. doi:10.1083/jcb.201408115. http://dx.doi.org/10.1083/jcb.201408115.0021-9525http://nrs.harvard.edu/urn-3:HUL.InstRepos:14351053Drosophila melanogaster follicle stem cells are controlled by Wingless (Wg) ligands secreted 50 µm away, raising the question of how long-distance Wg spreading occurs. In this issue of JCB, Wang and Page-McCaw (2014. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201403084) demonstrate a potential mechanism by which the heparan sulfate proteoglycan Dally-like (Dlp) promotes Wg travel, whereas matrix Mmp2 (Metalloproteinase 2) impedes it by inactivating Dlp.en-USCommentA sharp end to sugary Wingless travelsJournal Article2015-04-0110.1083/jcb.201408115