Wu, ChenWang, ZhaomingSong, XinFeng, Xiao-ShanAbnet, Christian C.He, JieHu, NanZuo, Xian-BoTan, WenZhan, QiminHu, ZhibinHe, ZhonghuJia, WeihuaZhou, YifengYu, KaiShu, Xiao-OuYuan, Jian-MinZheng, WeiZhao, Xue-KeGao, She-GanYuan, Zhi-QingZhou, Fu-YouFan, Zong-MinCui, Ji-LiLin, Hong-LiHan, Xue-NaLi, BeiChen, XiDawsey, Sanford M.Liao, LindaLee, Maxwell P.Ding, TiQiao, You-LinLiu, ZhihuaLiu, YuYu, DiankeChang, JiangWei, LixuanGao, Yu-TangKoh, Woon-PuayXiang, Yong-BingTang, Ze-ZhongFan, Jin-HuHan, Jing-JingZhou, Sheng-LiZhang, PengZhang, Dong-YunYuan, YuanHuang, YingLiu, ChunlingZhai, KanQiao, YanJin, GuangfuGuo, ChuanhaiFu, JianhuaMiao, XiaopingLu, ChangdongYang, HaijunWang, ChaoyuWheeler, William A.Gail, MitchellYeager, MeredithYuenger, JeffGuo, Er-TaoLi, Ai-LiZhang, WeiLi, Xue-MinSun, Liang-DanMa, Bao-GenLi, YanTang, SaPeng, Xiu-QingLiu, JingHutchinson, AmyJacobs, KevinGiffen, CarolBurdette, LaurieFraumeni, Joseph F.Shen, HongbingKe, YangZeng, YixinWu, TangchunKraft, PhillipChung, Charles C.Tucker, Margaret A.Hou, Zhi-ChaoLiu, Ya-LiHu, Yan-LongWang, LiYuan, GuoChen, Li-ShaLiu, XiaoMa, TengMeng, HuiSun, LiLi, Xin-MinLi, Xiu-MinKu, Jian-WeiZhou, Ying-FaYang, Liu-QinWang, ZhouLi, YinQige, QirenwangYang, Wen-JunLei, Guang-YanChen, Long-QiLi, En-MinYuan, LingYue, Wen-BinWang, RanWang, Lu-WenFan, Xue-PingZhu, Fang-HengZhao, Wei-XingMao, Yi-MinZhang, MeiXing, Guo-LanLi, Ji-LinHan, MinRen, Jing-LiLiu, BinRen, Shu-WeiKong, Qing-PengLi, FengSheyhidin, IlyarWei, WuZhang, Yan-RuiFeng, Chang-WeiWang, JinYang, Yu-HuaHao, Hong-ZhangBao, Qi-DeLiu, Bao-ChiWu, Ai-QunXie, DongYang, Wan-CaiWang, LiangZhao, Xiao-HangChen, Shu-QingHong, Jun-YanZhang, Xue-JunFreedman, Neal DGoldstein, Alisa M.Lin, DongxinTaylor, Philip R.Wang, Li-DongChanock, Stephen J.2015-04-012014Wu, C., Z. Wang, X. Song, X. Feng, C. C. Abnet, J. He, N. Hu, et al. 2014. “Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.” Nature genetics 46 (9): 1001-1006. doi:10.1038/ng.3064. http://dx.doi.org/10.1038/ng.3064.1061-4036http://nrs.harvard.edu/urn-3:HUL.InstRepos:14351125We conducted a joint (pooled) analysis of three genome-wide association studies (GWAS) 1-3 of esophageal squamous cell carcinoma (ESCC) in ethnic Chinese (5,337 ESCC cases and 5,787 controls) with 9,654 ESCC cases and 10,058 controls for follow-up. In a logistic regression model adjusted for age, sex, study, and two eigenvectors, two new loci achieved genome-wide significance, marked by rs7447927 at 5q31.2 (per-allele odds ratio (OR) = 0.85, 95% CI 0.82-0.88; P=7.72x10−20) and rs1642764 at 17p13.1 (per-allele OR= 0.88, 95% CI 0.85-0.91; P=3.10x10−13). rs7447927 is a synonymous single nucleotide polymorphism (SNP) in TMEM173 and rs1642764 is an intronic SNP in ATP1B2, near TP53. Furthermore, a locus in the HLA class II region at 6p21.32 (rs35597309) achieved genome-wide significance in the two populations at highest risk for ESSC (OR=1.33, 95% CI 1.22-1.46; P=1.99x10−10). Our joint analysis identified new ESCC susceptibility loci overall as well as a new locus unique to the ESCC high risk Taihang Mountain region.en-USJournal Article2015-04-0110.1038/ng.3064