Chen, JingSmith, Lois2017-08-172013Chen, Jing, and Lois E.H. Smith. 2013. Altered Cholesterol Homeostasis in Aged Macrophages Linked to Neovascular Macular Degeneration. Cell Metabolism 17, no. 4: 471–472. doi:10.1016/j.cmet.2013.03.010.1550-4131http://nrs.harvard.edu/urn-3:HUL.InstRepos:33776193Abnormal lipid metabolism has been linked to age-related macular degeneration (AMD); choroidal neovascularization in late AMD commonly causes blindness. Sene et al. (2013) now demonstrate that in aged macrophages decreased ABCA1 expression, regulated by liver X receptor and miR-33, impairs export of intracellular cholesterol, which promotes neovascular AMD.en-USJournal Article2017-08-1710.1016/j.cmet.2013.03.010