Gidon, AlexandreAl-Bataineh, Mohammad M.Jean-Alphonse, Frederic G.Stevenson, HilaryWatanabe, TomoyukiLouet, ClaireKhatri, AshokCalero, GuillermoPastor-Soler, Núria M.Gardella, ThomasVilardaga, Jean-Pierre2015-04-012014Gidon, A., M. M. Al-Bataineh, F. G. Jean-Alphonse, H. Stevenson, T. Watanabe, C. Louet, A. Khatri, et al. 2014. “Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase.” Nature chemical biology 10 (9): 707-709. doi:10.1038/nchembio.1589. http://dx.doi.org/10.1038/nchembio.1589.1552-4450http://nrs.harvard.edu/urn-3:HUL.InstRepos:14351271The PTH receptor is one of the first GPCR found to sustain cAMP signaling after internalization of the ligand–receptor complex in endosomes. This unexpected model is adding a new dimension on how we think about GPCR signaling, but its mechanism is incompletely understood. We report here that endosomal acidification mediated by the PKA action on the v-ATPase provides a negative feedback mechanism by which endosomal receptor signaling is turned-off.en-USJournal Article2015-04-0110.1038/nchembio.1589