Song, HonglinRamus, Susan JTyrer, JonathanBolton, Kelly LGentry-Maharaj, AleksandraWozniak, EvaAnton-Culver, HodaChang-Claude, JennyCramer, DanielDiCioccio, RichardDörk, ThiloGoode, Ellen LGoodman, Marc TSchildkraut, Joellen MSellers, ThomasBaglietto, LauraBeckmann, Matthias WBeesley, JonathanBlaakaer, JanCarney, Michael EChanock, StephenChen, ZhihuaCunningham, Julie MDicks, EdDoherty, Jennifer ADürst, MatthiasEkici, Arif BFenstermacher, DavidFridley, Brooke LGiles, GrahamGore, Martin EDe Vivo, ImmaculataHillemanns, PeterHogdall, ClausHogdall, EstridIversen, Edwin SJacobs, Ian JJakubowska, AnnaLi, DongLissowska, JolantaLubiński, , JanLurie, GalinaMcGuire, ValerieMcLaughlin, JohnMędrek, KrzysztofMoorman, Patricia GMoysich, KirstenNarod, StevenPhelan, CatherinePye, CaroleRisch, HarveyRunnebaum, Ingo BSeveri, GianlucaSouthey, MelissaStram, Daniel OThiel, Falk CTerry, KathrynTsai, Ya-YuTworoger, ShelleyVan Den Berg, David JVierkant, Robert AWang-Gohrke, ShanWebb, Penelope MWilkens, Lynne RWu, Anna HYang, HannahBrewster, WendyZiogas, ArgyriosHoulston, RichardTomlinson, IanWhittemore, Alice SRossing, Mary AnnePonder, Bruce A JPearce, Celeste LeighNess, Roberta BMenon, UshaKjaer, Susanne KrügerGronwald, JacekGarcia-Closas, MontserratFasching, Peter AEaston, Douglas FChenevix-Trench, GeorgiaBerchuck, AndrewPharoah, Paul D PGayther, Simon A2016-06-172009Song, Honglin, Susan J Ramus, Jonathan Tyrer, Kelly L Bolton, Aleksandra Gentry-Maharaj, Eva Wozniak, Hoda Anton-Culver, et al. 2009. “A Genome-Wide Association Study Identifies a New Ovarian Cancer Susceptibility Locus on 9p22.2.” Nat Genet 41 (9) (August 2): 996–1000. doi:10.1038/ng.424.1061-4036http://nrs.harvard.edu/urn-3:HUL.InstRepos:27334950Epithelial ovarian cancer has a major heritable component, but the known susceptibility genes explain less than half the excess familial risk1. We performed a genome wide association study (GWAS) to identify common ovarian cancer susceptibility alleles. We evaluated 507,094 SNPs genotyped in 1,817 cases and 2,353 controls from the UK and ~2 million imputed SNPs. We genotyped the 22,790 top ranked SNPs in 4,274 cases and 4,809 controls of European ancestry from Europe, USA and Australia. We identified 12 SNPs at 9p22 associated with disease risk (P<10−8). The most significant SNP (rs3814113; P = 2.5 × 10−17) was genotyped in a further 2,670 ovarian cancer cases and 4,668 controls confirming its association (combined data odds ratio = 0.82 95% CI 0.79 – 0.86, P-trend = 5.1 × 10−19). The association differs by histological subtype, being strongest for serous ovarian cancers (OR 0.77 95% CI 0.73 – 0.81, Ptrend = 4.1 × 10−21).en-USJournal Article2016-06-1710.1038/ng.424