Bolton, Kelly LTyrer, JonathanSong, HonglinRamus, Susan JNotaridou, MariaJones, ChrisSher, TanyaGentry-Maharaj, AleksandraWozniak, EvaTsai, Ya-YuWeidhaas, JoannePaik, DanielVan Den Berg, David JStram, Daniel OPearce, Celeste LeighWu, Anna HBrewster, WendyAnton-Culver, HodaZiogas, ArgyriosNarod, Steven ALevine, Douglas AKaye, Stanley BBrown, RobertPaul, JimFlanagan, JamesSieh, WeivaMcGuire, ValerieWhittemore, Alice SCampbell, IanGore, Martin ELissowska, JolantaYang, Hanna PMedrek, KrzysztofGronwald, JacekLubinski, JanJakubowska, AnnaLe, Nhu DCook, Linda SKelemen, Linda EBrook-Wilson, AngelaMassuger, Leon F A GKiemeney, Lambertus AAben, Katja K Hvan Altena, Anne MHoulston, RichardTomlinson, IanPalmieri, Rachel TMoorman, Patricia GSchildkraut, JoellenIversen, Edwin SPhelan, CatherineVierkant, Robert ACunningham, Julie MGoode, Ellen LFridley, Brooke LKruger-Kjaer, SusanBlaeker, JanHogdall, EstridHogdall, ClausGross, JennyKarlan, Beth YNess, Roberta BEdwards, Robert POdunsi, KunleMoyisch, Kirsten BBaker, Julie AModugno, FrancesmaryHeikkinenen, TuomasButzow, RalfNevanlinna, HeliLeminen, ArtoBogdanova, NataliaAntonenkova, NataliaDoerk, ThiloHillemanns, PeterDürst, MatthiasRunnebaum, IngoThompson, Pamela JCarney, Michael EGoodman, Marc TLurie, GalinaWang-Gohrke, ShanHein, RebeccaChang-Claude, JennyRossing, Mary AnneCushing-Haugen, Kara LDoherty, JenniferChen, ChuRafnar, ThorunnBesenbacher, SorenSulem, PatrickStefansson, KariBirrer, Michael J.Terry, KathrynHernandez, DenaCramer, DanielVergote, IgnaceAmant, FredericLambrechts, DietherDespierre, EvelynFasching, Peter ABeckmann, Matthias WThiel, Falk CEkici, Arif BChen, XiaoqingJohnatty, Sharon EWebb, Penelope MBeesley, JonathanChanock, StephenGarcia-Closas, MontserratSellers, TomEaston, Douglas FBerchuck, AndrewChenevix-Trench, GeorgiaPharoah, Paul D PGayther, Simon A2016-06-172010Bolton, Kelly L, Jonathan Tyrer, Honglin Song, Susan J Ramus, Maria Notaridou, Chris Jones, Tanya Sher, et al. 2010. “Common Variants at 19p13 Are Associated with Susceptibility to Ovarian Cancer.” Nat Genet 42 (10) (September 19): 880–884. doi:10.1038/ng.666.1061-4036http://nrs.harvard.edu/urn-3:HUL.InstRepos:27336915Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world accounting for 4 percent of deaths from cancer in women1. We performed a three-phase genome-wide association study of EOC survival in 8,951 EOC cases with available survival time data, and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P=5×10−4 and 6×10−4), but did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P=3×10−9 and 4×10−11 respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1 interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development.en-USJournal Article2016-06-1710.1038/ng.666