Amri, RamziBordeianou, LilianaSylla, PatriciaBerger, David2015-12-142015Amri, Ramzi, Liliana G. Bordeianou, Patricia Sylla, and David L. Berger. 2015. Colon cancer surgery following emergency presentation: effects on admission and stage-adjusted outcomes. American Journal of Surgery 209 (2): 246–253.0002-96101879-1883http://nrs.harvard.edu/urn-3:HUL.InstRepos:23927491Background: Emergency presentation with colon cancer is intuitively related to advanced disease. We measured its effect on outcomes of surgically treated colon cancer. Methods: A retrospective cohort of 1,071 surgical colon cancer patients (2004 to 2011), with 102 emergency cases requiring surgery within the index admission, was analyzed. Results: Emergency patients required longer surgeries (median 141 vs 124 minutes; P = .04), longer median admissions (8% vs 5%; P < .001), more readmissions (12.7% vs 7.1%; P = .040), and perioperative mortality (7.8% vs .8%; P < .001). Surgical pathology displayed higher rates of node-positive disease (56.6% vs 38.6%; P < .001), extramural vascular invasion (39.6% vs 29.1%; P = .021), and metastatic disease (19.6% vs 8%; P < .001). Consequently, adjusting for staging, emergency presentations had considerably higher mortality (odds ratio = 2.07; P = .003) and shorter disease-free survival (hazard ratio = 1.39; P = .042). Conclusions: Emergency presentation is a stage-independent poor prognostic factor associated with aggressive tumor biology, resulting in longer surgeries and admissions, frequent readmissions, worsening outcomes, and increasing healthcare costs.en-USEmergency surgeryColon cancerSurvivalDisease-free survivalPathologyPerioperative outcomesJournal Article2015-12-03Ramzi Amri, Liliana G. Bordeianou, Patricia Sylla, David L. Berger2016-02-0110.1016/j.amjsurg.2014.07.014