Tan, YanWu, FelixTamayo, PabloHaining, W. NicholasMesirov, Jill P.2015-12-042015Tan, Yan, Felix Wu, Pablo Tamayo, W. Nicholas Haining, and Jill P. Mesirov. 2015. “Constellation Map: Downstream visualization and interpretation of gene set enrichment results.” F1000Research 4 (1): 167. doi:10.12688/f1000research.6644.1. http://dx.doi.org/10.12688/f1000research.6644.1.2046-1402http://nrs.harvard.edu/urn-3:HUL.InstRepos:23845149Summary: Gene set enrichment analysis (GSEA) approaches are widely used to identify coordinately regulated genes associated with phenotypes of interest. Here, we present Constellation Map, a tool to visualize and interpret the results when enrichment analyses yield a long list of significantly enriched gene sets. Constellation Map identifies commonalities that explain the enrichment of multiple top-scoring gene sets and maps the relationships between them. Constellation Map can help investigators take full advantage of GSEA and facilitates the biological interpretation of enrichment results. Availability: Constellation Map is freely available as a GenePattern module at http://www.genepattern.org.en-USArticlesBioinformaticsGenetics of the Immune SystemGenomicsTheory & Simulationgene set enrichment analysisGSEAgene expressionsignaturepathwayvisualizationmutual informationJournal Article2015-12-0410.12688/f1000research.6644.1