Jiang, YinghuaFan, XiangYu, ZhanyangLiao, ZhengbuWang, Xiao-Shuvan Leyen, KlausSun, XiaochuanLo, EngWang, Xiaoying2015-12-042015Jiang, Yinghua, Xiang Fan, Zhanyang Yu, Zhengbu Liao, Xiao-Shu Wang, Klaus van Leyen, Xiaochuan Sun, Eng H. Lo, and Xiaoying Wang. 2015. “Combination Low-Dose Tissue-Type Plasminogen Activator Plus Annexin A2 for Improving Thrombolytic Stroke Therapy.” Frontiers in Cellular Neuroscience 9 (1): 397. doi:10.3389/fncel.2015.00397. http://dx.doi.org/10.3389/fncel.2015.00397.1662-5102http://nrs.harvard.edu/urn-3:HUL.InstRepos:23845185Risk of hemorrhagic transformation, incomplete reperfusion, neurotoxicity, and a short treatment time window comprises major challenges for tissue plasminogen activator (tPA) thrombolytic stroke therapy. Improving tPA therapy has become one of the highest priorities in the stroke field. This mini review article focuses on our recent efforts aimed at evaluating a novel combination approach of low-dose tPA plus recombinant annexin A2 (rA2, a tPA, and plasminogen co-receptor), which might enhance tPA thrombolytic efficacy, while reducing its associated complications related to intracerebral hemorrhagic transformation. Results of our experimental studies using a focal embolic stroke model in rats support the feasibility of the combination approach and suggest the potential for successful clinical translation.en-USMini Reviewcerebral ischemiatissue-type plasminogen activatorannexin A2thrombolysiscombination therapyfocal embolic stroke modelratsJournal Article2015-12-0410.3389/fncel.2015.00397