Jeselsohn, RinathBrown, Myles2016-05-022016Jeselsohn, Rinath, and Myles Brown. 2016. “How drug resistance takes shape.” eLife 5 (1): e14973. doi:10.7554/eLife.14973. http://dx.doi.org/10.7554/eLife.14973.2050-084Xhttp://nrs.harvard.edu/urn-3:HUL.InstRepos:26859918Mutations in a hormone receptor can lead to therapeutic resistance by making it less able to bind and respond to hormone blocking drugs and by making it active, even when the hormome is not present.en-USBreast CancerInsightbreast canceracquired drug resistancesomatic mutationestrogen receptor alphahormoneselective estrogen receptor modulatorsHumanJournal Article2016-05-0210.7554/eLife.14973