Itkin, TomerGur-Cohen, ShiriSpencer, Joel A.Schajnovitz, AmirRamasamy, Saravana K.Kusumbe, Anjali P.Ledergor, GuyJung, YookyungMilo, IdanPoulos, Michael G.Kalinkovich, AlexanderLudin, AyaKollet, OritShakhar, GuyButler, Jason M.Rafii, ShahinAdams, Ralf H.Scadden, DavidLin, CharlesLapidot, Tsvee2018-06-202016Itkin, Tomer, Shiri Gur-Cohen, Joel A. Spencer, Amir Schajnovitz, Saravana K. Ramasamy, Anjali P. Kusumbe, Guy Ledergor, et al. 2016. “Distinct Bone Marrow Blood Vessels Differentially Regulate Haematopoiesis.” Nature 532 (7599) (April 13): 323–328. doi:10.1038/nature17624.0028-0836http://nrs.harvard.edu/urn-3:HUL.InstRepos:37137066Bone marrow (BM) endothelial cells (BMECs) form a network of blood vessels (BVs) which regulate both leukocyte trafficking and hematopoietic stem and progenitor cell (HSPC) maintenance. However, it is not clear how BMECs balance these dual roles and if these events occur at the same vascular site. We found that BM stem cell maintenance and leukocyte trafficking are regulated by distinct BV types with different permeability properties. Less permeable arterial BVs maintain HSCs in a low reactive oxygen species (ROS) state, whereas the more permeable sinusoids promote HSPC activation and are the exclusive site for immature and mature leukocyte trafficking to and from the BM. A functional consequence of high BVs permeability is that exposure to blood plasma increases BM HSPC ROS levels, augmenting their migration capacity while compromising their long term repopulation and survival potential. These findings may have relevance for clinical hematopoietic stem cell transplantation and mobilization protocols.en-USJournal Article2018-06-2010.1038/nature17624