Kelemen, Linda ELawrenson, KateTyrer, JonathanLi, QiyuanLee, Janet MSeo, Ji-HeuiPhelan, Catherine MBeesley, JonathanChen, XiaoqingSpindler, Tassja JAben, Katja K HAnton-Culver, HodaAntonenkova, NataliaBaker, HelenBandera, Elisa VBean, YukieBeckmann, Matthias WBisogna, MariaBjorge, LineBogdanova, NataliaBrinton, Louise ABrooks-Wilson, AngelaBruinsma, FionaButzow, RalfCampbell, Ian GCarty, KarenChang-Claude, JennyChen, Y AnnChen, ZhihuaCook, Linda SCramer, DanielCunningham, Julie MCybulski, CezaryDansonka-Mieszkowska, AgnieszkaDennis, JoeDicks, EdDoherty, Jennifer ADörk, Thilodu Bois, AndreasDürst, MatthiasEccles, DianaEaston, Douglas TEdwards, Robert PEilber, UrsulaEkici, Arif BEngelholm, Svend AageFasching, Peter AFridley, Brooke LGao, Yu-TangGentry-Maharaj, AleksandraGiles, Graham GGlasspool, RosalindGoode, Ellen LGoodman, Marc TGrownwald, JacekHarrington, PatriciaHarter, PhilippHasmad, Hanis NazihahHein, AlexanderHeitz, FlorianHildebrandt, Michelle A THillemanns, PeterHogdall, EstridHogdall, ClausHosono, SatoyoIversen, Edwin SJakubowska, AnnaJensen, AllanJi, Bu-TianKarlan, Beth YKellar, MelissaKelley, Joseph LKiemeney, Lambertus AKrakstad, CamillaKjaer, Susanne KKupryjanczyk, JolantaLambrechts, DietherLambrechts, SandrinaLe, Nhu DLee, Alice WLele, ShashiLeminen, ArtoLester, JennyLevine, Douglas ALiang, DongLissowska, JolantaLu, KarenLubinski, JanLundvall, LeneMassuger, Leon F A GMatsuo, KeitaroMcGuire, ValerieMcLaughlin, John RMcNeish, IainMenon, UshaModugno, FrancesmaryMoes-Sosnowska, JoannaMoysich, Kirsten BNarod, Steven ANedergaard, LotteNess, Roberta BNevanlinna, HeliAdenan, Noor Azmi MatOdunsi, KunleOlson, Sara HOrlow, IreneOrsulic, SandraWeber, Rachel PalmieriPaul, JamesPearce, Celeste LeighPejovic, TanjaPelttari, Liisa MPermuth-Wey, JenniferPike, Malcolm CPoole, Elizabeth M.Ramus, Susan JRisch, Harvey ARosen, BarryRossing, Mary AnneRothstein, Joseph HRudolph, AnjaRunnebaum, Ingo BRzepecka, Iwona KSalvesen, Helga BSchildkraut, Joellen MSchwaab, IraShu, Xiao-OuShvetsov, Yurii BSiddiqui, NadeemSieh, WeivaSong, HonglinSouthey, Melissa CSucheston, LaraTangen, Ingvild LTeo, Soo-HwangTerry, Kathryn LThompson, Pamela JTworoger, Shelleyvan Altena, Anne MVan Nieuwenhuysen, ElsVergote, IgnaceVierkant, Robert AWang-Gohrke, ShanWalsh, ChristineWentzensen, NicolasWhittemore, Alice SWicklund, Kristine GWilkens, Lynne RSawicki, WlodzimierzWoo, Yin-LingWu, XifengWu, Anna HYang, HannahZheng, WeiZiogas, ArgyriosSellers, Thomas AFreedman, Matthew LChenevix-Trench, GeorgiaPharoah, Paul D PGayther, Simon ABerchuck, Andrew2017-04-212015Kelemen, Linda E, Kate Lawrenson, Jonathan Tyrer, Qiyuan Li, Janet M Lee, Ji-Heui Seo, Catherine M Phelan, et al. 2015. Genome-Wide Significant Risk Associations for Mucinous Ovarian Carcinoma. Nat Genet 47, no. 8: 888–897.1061-4036http://nrs.harvard.edu/urn-3:HUL.InstRepos:32303180Genome-wide association studies have identified several risk associations for ovarian carcinomas but not for mucinous ovarian carcinomas (MOCs). Our analysis of 1,644 MOC cases and 21,693 controls with imputation identified 3 new risk associations: rs752590 at 2q13 (P = 3.3 × 10−8), rs711830 at 2q31.1 (P = 7.5 × 10−12) and rs688187 at 19q13.2 (P = 6.8 × 10−13). We identified significant expression quantitative trait locus (eQTL) associations for HOXD9 at 2q31.1 in ovarian (P = 4.95 × 10−4, false discovery rate (FDR) = 0.003) and colorectal (P = 0.01, FDR = 0.09) tumors and for PAX8 at 2q13 in colorectal tumors (P = 0.03, FDR = 0.09). Chromosome conformation capture analysis identified interactions between the HOXD9 promoter and risk-associated SNPs at 2q31.1. Overexpressing HOXD9 in MOC cells augmented the neoplastic phenotype. These findings provide the first evidence for MOC susceptibility variants and insights into the underlying biology of the disease.en-USgenome-wide association studiesovarian cancerJournal Article2017-04-2110.1038/ng.3336