Xia, ZongqiWhite, Charles C.Owen, Emily K.Von Korff, AlinaClarkson, Sarah R.McCabe, CristinCimpean, MariaWinn, Phoebe A.Hoesing, AshleySteele, Sonya U.Cortese, Irene C. M.Chitnis, TanujaWeiner, HowardReich, Daniel S.Chibnik, LoriDe Jager, Philip2021-10-082016-02Xia, Zongqi, Charles C. White, Emily K. Owen, Alina Von Korff, Sarah R. Clarkson, Cristin McCabe, Maria Cimpean et al. "Genes and Environment in Multiple Sclerosis Project: A Platform to Investigate Multiple Sclerosis Risk." Annals of Neurology 79, no. 2 (2016): 178-189. DOI: 10.1002/ana.245600364-51341531-8249https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37369727The Genes and Environment in Multiple Sclerosis (GEMS) project establishes a platform to investigate the events leading to MS in at-risk individuals. It has recruited 2,632 first-degree relatives from across the USA. Using an integrated genetic and environmental risk score, we identified subjects with twice the MS risk when compared to the average family member, and we report an initial incidence rate in these subjects that is 30 times greater than that of sporadic MS. We discuss the feasibility of large-scale studies of asymptomatic at-risk subjects that leverage modern tools of subject recruitment to execute collaborative projects.en-USResearch Subject Categories::MEDICINE::Dermatology and venerology,clinical genetics, internal medicine::Internal medicine::NeurologyJournal Article2017-09-2220162021-10-0810.1002/ana.24560