Awad, Karim M.Malhotra, AtulBarnet, Jodi H.Quan, StuartPeppard, Paul E.2022-07-212012-05Awad, Karim M., Atul Malhotra, Jodi H. Barnet, Stuart Quan, Paul E. Peppard. "Exercise Is Associated with a Reduced Incidence of Sleep-Disordered Breathing." American Journal of Medicine 125, no. 5 (2012): 485-490. DOI: 10.1016/j.amjmed.2011.11.0250002-93431555-7162https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37372775Background The effect of exercise on sleep-disordered breathing is unknown. While diet and weight loss have been shown to reduce the severity of sleep-disordered breathing, it is unclear whether exercise has an independent effect. Methods A population-based longitudinal epidemiologic study of adults measured the association between exercise and incidence and severity of sleep-disordered breathing. Hours of weekly exercise were assessed by two mailed surveys (1988 and 2000). Sleep-disordered breathing was assessed by 18-channel in-laboratory polysomnography at baseline and at follow up. Results Associations were modeled using linear and logistic regression, adjusting for body mass index, age, sex, and other covariates. Hours of exercise were associated with reduced incidence of mild (Odds Ratio = 0.76, p= 0.011) and moderate (Odds Ratio = 0.67, p= 0.002) sleep-disordered breathing. Also a decrease in exercise duration was associated with worsening sleep-disordered breathing, as measured by the apnea-hypopnea index, AHI (ß = 2.368, p= 0.048). Adjustment for body mass index attenuated these effects. Conclusions Exercise is associated with a reduced incidence of mild and moderate sleep-disordered breathing and decreasing exercise is associated with worsening of sleep-disordered breathing. The effect of exercise on sleep-disordered breathing appears to be largely, but perhaps not entirely, mediated by changes in body habitus.en-USGeneral MedicineJournal Article2018-02-2320122022-07-2110.1016/j.amjmed.2011.11.025