Liu, JieJia, XinJia, SenhaoQin, XianhuiZhang, TaoLiu, LishunLi, HaiboRong, DanZhou, ZiyiSong, YuxiangZuo, ShangweiDuan, ChenWu, ZhongyinWei, RenGe, YangyangWang, XianKong, WeiXu, XipingKhalil, RaoufHuo, YongGuo, Wei2017-12-062017Liu, J., X. Jia, S. Jia, X. Qin, T. Zhang, L. Liu, H. Li, et al. 2017. “Small infrarenal aortic diameter associated with lower-extremity peripheral artery disease in Chinese hypertensive adults.” Scientific Reports 7 (1): 14547. doi:10.1038/s41598-017-12587-x. http://dx.doi.org/10.1038/s41598-017-12587-x.http://nrs.harvard.edu/urn-3:HUL.InstRepos:34493205Several studies suggest that infrarenal aortic diameter is associated with lower-extremity peripheral artery disease (LE-PAD). However, data regarding the associations between infrarenal aortic diameter and LE-PAD are limited, especially in large sample populations and Asian or Chinese populations. Our analysis included 17279 Chinese hypertensive adults comprising 6590 men and 10689 women with a mean age of 64.74 ± 7.41 years. Participants were selected from 22693 candidates from two large population-based cohort-studies. The primary noninvasive test for diagnosis of LE-PAD is the ankle–brachial index (ABI) at rest and typically an ABI ≤ 0.90 is used to define LE-PAD. The prevalence of LE-PAD was found to significantly decrease as the aortic diameter increased according to the tertile of the aortic diameter. LE-PAD was significantly more prevalent in the lowest tertile (OR = 1.58, 95% CI = 1.29–1.94, p < 0.001) and similarly prevalent in the highest tertile (OR = 0.92, 95% CI = 0.73–1.16, p = 0.49) when compared with the median tertile. No significant interactions between the aortic diameter and any of the stratified variables were found (all p > 0.05). In conclusion, Small aortic diameter (as opposed to large aortic diameter) is significantly associated with LE-PAD in Chinese hypertensive adults.en-USJournal Article2017-12-0610.1038/s41598-017-12587-x