Ikram, M. ArfanBrusselle, Guy G. O.Murad, Sarwa Darwishvan Duijn, Cornelia M.Franco, Oscar H.Goedegebure, AndréKlaver, Caroline C. W.Nijsten, Tamar E. C.Peeters, Robin P.Stricker, Bruno H.Tiemeier, HenningUitterlinden, André G.Vernooij, Meike W.Hofman, Albert2017-12-062017Ikram, M. A., G. G. O. Brusselle, S. D. Murad, C. M. van Duijn, O. H. Franco, A. Goedegebure, C. C. W. Klaver, et al. 2017. “The Rotterdam Study: 2018 update on objectives, design and main results.” European Journal of Epidemiology 32 (9): 807-850. doi:10.1007/s10654-017-0321-4. http://dx.doi.org/10.1007/s10654-017-0321-4.http://nrs.harvard.edu/urn-3:HUL.InstRepos:34493344The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, otolaryngological, locomotor, and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over comprise the Rotterdam Study cohort. Since 2016, the cohort is being expanded by persons aged 40 years and over. The findings of the Rotterdam Study have been presented in over 1500 research articles and reports (see www.erasmus-epidemiology.nl/rotterdamstudy). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods.en-USBiomarkersCardiovascular diseasesCohort studyDermatological diseasesEndocrine diseasesEpidemiologic methodsGenetic epidemiologyLiver diseasesNeurological diseasesOncologyOphthalmic diseasesOtolaryngological diseasesPharmacoepidemiologyRenal diseasesPsychiatric diseasesRespiratory diseasesJournal Article2017-12-0610.1007/s10654-017-0321-4