Zhu, ZhaozhongLee, PhilChaffin, MarkChung, WonilLoh, Po-RuLu, QuanChristiani, DavidLiang, Liming2021-05-072018-05-21Zhu, Zhaozhong, Phil Hyoun Lee, Mark Chaffin, Wonil Chung, Po-Ru Loh, Quan Lu, David Christopher Christiani et al. "A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases." Nat Genet 50, no. 6 (2018): 857-864. DOI: 10.1038/s41588-018-0121-01061-40361546-1718https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37367488Clinical and epidemiological data suggest that asthma and allergic diseases are associated and may share a common genetic etiology. We analyzed genome-wide SNP data for asthma and allergic diseases in 33,593 cases and 76,768 controls of European ancestry from UK Biobank. Two publicly available independent genome-wide association studies were used for replication. We have found a strong genome-wide genetic correlation between asthma and allergic diseases (rg = 0.75, P = 6.84 × 10−62). Cross-trait analysis identified 38 genome-wide significant loci, including 7 novel shared loci. Computational analysis showed that shared genetic loci are enriched in immune/inflammatory systems and tissues with epithelium cells. Our work identifies common genetic architectures shared between asthma and allergy and will help to advance understanding of the molecular mechanisms underlying co-morbid asthma and allergic diseases.en-USGeneticsJournal Article2018-02-0820182021-05-0710.1038/s41588-018-0121-0