Daniel, CarolinWeigmann, Bennovon Boehmer, Harald2018-02-262017Daniel, Carolin, Benno Weigmann, and Harald von Boehmer. 2017. “Reply to “Tolerogenic insulin peptide therapy precipitates type 1 diabetes”.” The Journal of Experimental Medicine 214 (7): 2157-2159. doi:10.1084/jem.20170285. http://dx.doi.org/10.1084/jem.20170285.http://nrs.harvard.edu/urn-3:HUL.InstRepos:34868756In this issue of JEM, Bergman et al. (https://doi.org/10.1084/jem.20160471) challenge the data published in our previous JEM paper on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Here, we provide a response to these data and suggest that appropriate subimmunogenic conditions are required to induce Foxp3+ regulatory T cell conversion.en-USReplyJournal Article2018-02-2610.1084/jem.20170285