Mobark, Nahla AliAl-Harbi, MusaMosleh, OthmanSantagata, SandroSnuderl, MatijaAbedalthagafi, Malak2018-02-262018Mobark, Nahla Ali, Musa Al-Harbi, Othman Mosleh, Sandro Santagata, Matija Snuderl, and Malak Abedalthagafi. 2018. “A case of molecularly profiled extraneural medulloblastoma metastases in a child.” BMC Medical Genetics 19 (1): 10. doi:10.1186/s12881-018-0526-8. http://dx.doi.org/10.1186/s12881-018-0526-8.http://nrs.harvard.edu/urn-3:HUL.InstRepos:34868816Background: Extraneural metastases are relatively rare manifestations of medulloblastoma. Case presentation: We present the case of a young boy with group three MYCN-amplified medulloblastoma. He received multimodal chemotherapy consisting of gross total resection followed by postoperative craniospinal radiation and adjuvant chemotherapy. The patient developed extraneural metastases 4 months after the end of therapy. Literature review identifies the poor prognosis of MYCN-amplified medulloblastomas as well as extraneural metastases; we review the current limitations and future directions of medulloblastoma treatment options. Conclusion: To the best of our knowledge, this is the first molecularly characterized report of extraneural metastases of medulloblastoma in a child.en-USExtraneural metastasisMedulloblastomaNGSMethylationJournal Article2018-02-2610.1186/s12881-018-0526-8