Hydbring, PerWang, YinanBogorad, Roman L.Yin, HaoAnderson, DanielLi, ChengSicinski, Piotr2018-02-262017Hydbring, Per, Yinan Wang, Roman L. Bogorad, Hao Yin, Daniel G. Anderson, Cheng Li, and Piotr Sicinski. 2017. “Identification of cell cycle-targeting microRNAs through genome-wide screens.” Cell Cycle 16 (23): 2241-2248. doi:10.1080/15384101.2017.1380132. http://dx.doi.org/10.1080/15384101.2017.1380132.http://nrs.harvard.edu/urn-3:HUL.InstRepos:34868829ABSTRACT By performing nine genome-wide microRNA (miRNA) screens, we recently uncovered a new class of miRNAs, which target multiple cyclins and cyclin-dependent kinases (CDKs). Systemic delivery of selected cell cycle-targeting miRNAs to mouse xenograft models resulted in potent anti-tumorigenic effects without affecting animals' health. Here, we provide an in-depth description of our miRNA screening methodology, analyses of selected cell cycle-targeting miRNAs, and discuss why miRNA therapy might be a viable therapeutic option for cancer patients.en-UScyclinscyclin-dependent kinasescell cyclecancermicroRNAsJournal Article2018-02-2610.1080/15384101.2017.1380132