Malikova, Marina ATkacz, Jaroslaw NSlanetz, PriscillaGuo, Chao-YuAakil, AdamJara, Hernan2017-12-052017Malikova, Marina A, Jaroslaw N Tkacz, Priscilla J Slanetz, Chao-Yu Guo, Adam Aakil, and Hernan Jara. 2017. “Evaluation of T1/T2 ratios in a pilot study as a potential biomarker of biopsy: proven benign and malignant breast lesions in correlation with histopathological disease stage.” Future Science OA 3 (3): FSO197. doi:10.4155/fsoa-2016-0063. http://dx.doi.org/10.4155/fsoa-2016-0063.http://nrs.harvard.edu/urn-3:HUL.InstRepos:34492001Aim: Early breast cancer detection is important for intervention and prognosis. Advances in treatment and outcome require diagnostic tools with highly positive predictive value. Purpose: To study the potential role of quantitative MRI (qMRI) using T1/T2 ratios to differentiate benign from malignant breast lesions. Methods: A cross-sectional study of 69 women with 69 known or suspicious breast lesions were scanned with mixed-turbo spin echo pulse sequence. Patients were grouped according to histopathological assessment of disease stage: untreated malignant tumor, treated malignancy and benign disease. Results & Discussion: Elevated T1/T2 means were observed for biopsy-proven malignant lesions and for malignant lesions treated prior to qMRI with chemotherapy and/or radiation, as compared with benign lesions. The qMRI-obtained T1/T2 ratios correlated with histopathology. Analysis revealed correlation between elevated T1/T2 ratio and disease stage. This could provide valuable complementary information on tissue properties as an additional diagnostic tool.en-USbreast imagingdevelopment of potential biomarker for evaluation of breast diseasemagnetic resonance imagingquantitative magnetic resonance imagingJournal Article2017-12-0510.4155/fsoa-2016-0063